Nunzio Bottini Selected Research

Type 1 Diabetes Mellitus (Autoimmune Diabetes)

11/2015	Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice.
3/2009	Conjugation of antisense oligonucleotides to PEGylated carbon nanotubes enables efficient knockdown of PTPN22 in T lymphocytes.
9/2007	Protein tyrosine phosphatase PTPN22 in human autoimmunity.
8/2006	Role of PTPN22 in type 1 diabetes and other autoimmune diseases.
4/2004	A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes.

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Nunzio Bottini Research Topics

Disease

13	Rheumatoid Arthritis 03/2024 - 09/2007
11	Neoplasms (Cancer) 02/2024 - 07/2002
9	Arthritis (Polyarthritis) 11/2023 - 07/2013
9	Autoimmune Diseases (Autoimmune Disease) 12/2022 - 09/2007
8	Inflammation (Inflammations) 02/2024 - 03/2009
5	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 11/2015 - 04/2004
4	Fibrosis (Cirrhosis) 01/2023 - 10/2017
4	Obesity 01/2021 - 09/2000
3	Rheumatic Diseases (Rheumatism) 02/2024 - 05/2017
3	Experimental Arthritis 11/2023 - 01/2019
3	Insulin Resistance 01/2021 - 10/2009
3	Osteoarthritis 05/2016 - 12/2014
3	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2012 - 08/2005
2	Systemic Scleroderma (Systemic Sclerosis) 01/2022 - 05/2017
2	Hypertrophy 01/2021 - 01/2002
2	Juvenile Arthritis (Juvenile Idiopathic Arthritis) 10/2014 - 09/2007
2	Plague (Bubonic Plague) 03/2005 - 02/2004
1	Poxviridae Infections 01/2023
1	Vaccinia 01/2023
1	Mpox (monkeypox) 01/2023
1	Smallpox (Variola) 01/2023
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2021
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 10/2020
1	Necrosis 01/2016
1	Cardiomyopathies (Cardiomyopathy) 12/2015
1	Heart Diseases (Heart Disease) 12/2015
1	Poisoning 01/2015
1	Adenoma (Adenomas) 09/2014
1	Carcinogenesis 09/2014
1	Infections 01/2014
1	Communicable Diseases (Infectious Diseases) 07/2013
1	Colitis 07/2013
1	Experimental Melanoma 06/2013
1	Coronary Artery Disease (Coronary Atherosclerosis) 01/2009
1	Vitiligo 09/2007
1	Graves Disease (Basedow Disease) 09/2007
1	Thyroid Diseases (Thyroid Disease) 08/2005
1	Paralysis (Palsy) 03/2005
1	Hypertriglyceridemia 11/2002
1	Tourette Syndrome (Tourette's Syndrome) 09/2002

Drug/Important Bio-Agent (IBA)

18	Phosphoric Monoester Hydrolases (Phosphatases)IBA 02/2024 - 07/2002
15	Protein Tyrosine PhosphatasesIBA 02/2024 - 01/2002
11	Tyrosine (L-Tyrosine)FDA Link 02/2024 - 02/2004
6	Proteins (Proteins, Gene)FDA Link 01/2019 - 09/2000
4	Proteoglycans (Proteoglycan)IBA 11/2023 - 05/2015
4	src-Family KinasesIBA 01/2023 - 06/2012
4	Acid PhosphataseIBA 01/2012 - 09/2002
3	CytokinesIBA 02/2024 - 01/2014
3	Phosphotransferases (Kinase)IBA 01/2022 - 09/2014
3	Phosphates (Orthophosphate)IBA 05/2017 - 07/2002
2	6-pyruvoyltetrahydropterin synthase (PTPS)IBA 02/2024 - 09/2012
2	Virulence Factors (Pathogenicity Factors)IBA 01/2023 - 02/2004
2	Antirheumatic Agents (DMARD)IBA 01/2023 - 01/2020
2	Phosphoprotein Phosphatases (Phosphatases, Protein)IBA 01/2023 - 01/2023
2	Non-Receptor Type 2 Protein Tyrosine PhosphataseIBA 12/2022 - 10/2020
2	T-Cell Antigen Receptors (T-Cell Receptor)IBA 12/2022 - 09/2012
2	Insulin ReceptorIBA 01/2021 - 01/2021
2	EnzymesIBA 05/2017 - 06/2013
2	MicroRNAs (MicroRNA)IBA 01/2017 - 11/2013
2	Insulin (Novolin)FDA Link 11/2015 - 10/2009
2	LigandsIBA 01/2014 - 06/2013
1	AntigensIBA 02/2024
1	PhosphotyrosineIBA 01/2023
1	VaccinesIBA 01/2023
1	Dual-Specificity PhosphatasesIBA 01/2023
1	3- (2- methoxyphenyl)- 5- methoxy- 1,3,4- oxadiazol- 2(3H)- oneIBA 01/2023
1	PhosphoserineIBA 01/2023
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 12/2022
1	LipidsIBA 05/2022
1	ChemokinesIBA 01/2022
1	Antifibrotic AgentsIBA 01/2022
1	purineIBA 01/2021
1	Tumor Necrosis Factor InhibitorsIBA 01/2020
1	Cysteine (L-Cysteine)FDA Link 01/2019
1	Methotrexate (Mexate)FDA LinkGeneric 01/2019
1	AlbuminsIBA 01/2019
1	Bleomycin (Blenoxane)FDA LinkGeneric 10/2017
1	Tyrosine Kinase InhibitorsIBA 05/2017
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 05/2017
1	Histones (Histone)IBA 01/2017
1	Non-Receptor Type 11 Protein Tyrosine PhosphataseIBA 05/2016
1	Platelet-Derived Growth FactorIBA 01/2016
1	Interleukin-1 (Interleukin 1)IBA 01/2016
1	Botulinum Toxins (Botulinum Toxin)IBA 01/2015
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 09/2014
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 09/2014
1	Ion Channels (Ion Channel)IBA 09/2014
1	Antiviral Agents (Antivirals)IBA 07/2013
1	TNF Receptor-Associated Factor 3IBA 07/2013
1	Inflammation MediatorsIBA 05/2013
1	Glucose (Dextrose)FDA LinkGeneric 10/2009
1	Biomarkers (Surrogate Marker)IBA 03/2009
1	Adenosine DeaminaseIBA 01/2009
1	Type III Secretion SystemsIBA 03/2005
1	Non-Receptor Type 22 Protein Tyrosine PhosphataseIBA 04/2004
1	Triglycerides (Triacylglycerol)IBA 11/2002
1	Phosphatidylinositols (Phosphatidylinositol)IBA 07/2002

Therapy/Procedure

10	Therapeutics 02/2024 - 03/2011
4	Immunotherapy 11/2023 - 03/2009
1	Lasers (Laser) 03/2024